Areas of Research

The LMRN research themes cover the spectrum of Liver Metastasis from its etiology (genetic origins), biology (molecular attributes) and spread (metastasis) to translation of its discoveries such as genetic testing for cancer risk, patient stratification for treatment for breast and pancreatic carcinomas, and management of metastasis of colorectal cancer and radiologic treatment regimens.

Group Publications

Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights.

Latacz E, Höppener D, Bohlok A, Leduc S, Tabariès S, Fernández Moro C, Lugassy C, Nyström H, Bozóky B,Floris G, Geyer N, Brodt P, Llado L, Van Mileghem L, De Schepper M, Majeed AW, Lazaris A, Dirix P, Zhang Q, Petrillo SK, Vankerckhove S, Joye I, Meyer Y, Gregorieff A, Roig NR, Vidal-Vanaclocha F, Denis L, Oliveira RC, Metrakos P, Grünhagen DJ, Nagtegaal ID, Mollevi DG, Jarnagin WR, D'Angelica MI, Reynolds AR, Doukas M, Desmedt C, Dirix L, Donckier V, Siegel PM, Barnhill R, Gerling M, Verhoef C, Vermeulen PB.
Br J Cancer. 2022 Oct;127(6):988-1013. doi: 10.1038/s41416-022-01859-7. Epub 2022 Jun 1.PMID: 35650276

Limitations in resectability of colorectal liver metastases 2020 - A systematic approach for clinicians and patients.

Schadde E, Grunhagen DJ, Verhoef C, Krzywon L, Metrakos P.
Semin Cancer Biol. 2021 Jun;71:10-20. doi: 10.1016/j.semcancer.2020.09.008. Epub 2020 Sep 24.PMID: 32980499

Tumor microenvironment conditions that favor vessel co-option in colorectal cancer liver metastases: A theoretical model.

Rada M, Lazaris A, Kapelanski-Lamoureux A, Mayer TZ, Metrakos P.

Semin Cancer Biol. 2021 Jun;71:52-64. doi: 10.1016/j.semcancer.2020.09.001. Epub 2020 Sep 10.PMID: 32920126

The unique immune microenvironment of liver metastases: Challenges and opportunities.

Ciner AT, Jones K, Muschel RJ, Brodt P.
Semin Cancer Biol. 2021 Jun;71:143-156. doi: 10.1016/j.semcancer.2020.06.003. Epub 2020 Jun 8.PMID: 32526354

International consensus guidelines for scoring the histopathological growth patterns of liver metastasis.

van Dam PJ, van der Stok EP, Teuwen LA, Van den Eynden GG, Illemann M, Frentzas S, Majeed AW, Eefsen RL,
Coebergh van den Braak RRJ, Lazaris A, Fernandez MC, Galjart B, Laerum OD, Rayes R, Grünhagen DJ,
Van de Paer M, Sucaet Y, Mudhar HS, Schvimer M, Nyström H, Kockx M, Bird NC, Vidal-Vanaclocha F, Metrakos P, Simoneau E, Verhoef C, Dirix LY, Van Laere S, Gao ZH, Brodt P, Reynolds AR, Vermeulen PB.
Br J Cancer. 2017 Nov 7;117(10):1427-1441. doi: 10.1038/bjc.2017.334. Epub 2017 Oct 5.PMID: 28982110